Glycosylceramide metabolic process

Across TCGA cell cohorts, RNA activity of the Glycosylceramide metabolic process pathway is significantly associated with the drug response of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Cyclophosphamide, PFI3, and Bexarotene, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Cyclophosphamide grouped by Glycosylceramide metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cyclophosphamide →	-0.264	-0.263	.001	.012	3	2
LARGE_INTESTINE	PFI3 →	-0.653	-0.332	.001	.006	3	2
PANCREAS	Bexarotene →	-0.859	-0.548	.004	.025	3	2
PANCREAS	PI-103 →	+1.337	+0.462	.004	.013	3	2
LARGE_INTESTINE	ZG-10 →	+1.237	+0.284	.035	.035	3	1
LARGE_INTESTINE	QL-VIII-58 →	+1.138	+0.284	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Cyclophosphamide by Glycosylceramide metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →