Ceramide metabolic process

Across TCGA patient cohorts, RNA activity of the Ceramide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF2, CALHM5, and C8orf88, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide metabolic process activity versus RASSF2 in HNSC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RASSF2 →	-0.812	-0.164	.001	.002	3	5
UCEC	CALHM5 →	-0.365	-0.196	.008	.002	3	4
UCEC	C8orf88 →	-0.598	-0.235	.004	<.001	3	4
HNSC	PALD1 →	-0.817	-0.172	<.001	<.001	3	4
LUAD	RFTN1 →	-0.478	-0.156	.001	.001	3	4
LUAD	PLCL2 →	-0.264	-0.122	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006672 vs RASSF2 — HNSC

Explore this scatter interactively →