Ceramide metabolic process

Across TCGA cell cohorts, RNA activity of the Ceramide metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SORBS1, MYBL2, and ELK4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SORBS1 grouped by Ceramide metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SORBS1 →	+0.298	+0.070	.009	.001	3	6
LUNG_NSCLC_LUSC	MYBL2 →	-0.895	-0.103	.001	.004	3	5
LUNG_NSCLC_LUSC	ELK4 →	-0.224	-0.107	.008	.001	3	5
BONE	MAX →	-0.600	-0.139	.001	.003	3	5
CNS	IL12RB1 →	-0.336	-0.086	.006	.001	2	5
CNS	FERMT2 →	+0.481	+0.084	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SORBS1 by Ceramide metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →