Ceramide metabolic process

Across TCGA cell cohorts, RNA activity of the Ceramide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUMF1, NEU1, and HNRNPC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide metabolic process activity versus SUMF1 in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SUMF1 →	+0.869	+1.008	<.001	.002	3	8
BLOOD_Lymphoma	NEU1 →	+1.535	+1.471	<.001	<.001	3	6
SKIN	HNRNPC →	-0.566	-0.259	.007	.001	3	6
LUNG_SCLC	HEXB →	+1.503	+1.226	<.001	.001	3	5
SKIN	CTSA →	+1.269	+0.267	.002	.004	3	5
BLOOD_Leukemia	CTSZ →	+2.990	+0.842	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006672 vs SUMF1 — BLOOD_Leukemia

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