Phosphatidylinositol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YME1L1, RPL5, and SERBP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol biosynthetic process activity versus YME1L1 in OV (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	YME1L1 →	-0.258	-0.038	.001	<.001	3	10
BRCA	RPL5 →	-0.201	-0.021	<.001	<.001	3	9
HNSC	SERBP1 →	-0.232	-0.036	<.001	.005	2	9
CCRCC	RPS2 →	-0.264	-0.037	<.001	<.001	3	8
GBM	SEPTIN4 →	+0.576	+0.026	.001	.003	3	8
CCRCC	RPL10A →	-0.220	-0.031	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006661 vs YME1L1 — OV

Explore this scatter interactively →