Phosphatidylinositol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POP7, LARP4P, and ST7-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol biosynthetic process activity versus POP7 in CCRCC (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	POP7 →	-0.278	-0.649	.001	.004	3	4
CCRCC	LARP4P →	-0.217	-0.758	.007	<.001	3	4
OV	ST7-AS1 →	-0.487	-0.849	<.001	.005	3	3
COAD	MUS81 →	-0.332	-0.148	.006	.009	2	4
CCRCC	MRGBP →	-0.223	-0.578	<.001	.002	3	3
CCRCC	RPL18A →	-0.292	-0.496	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006661 vs POP7 — CCRCC

Explore this scatter interactively →