Phosphatidylinositol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC93, PIKFYVE, and PLEKHA3, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol biosynthetic process activity versus CCDC93 in OESOPHAGUS (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CCDC93 →	+1.083	+0.063	<.001	<.001	3	19
BLOOD_Lymphoma	PIKFYVE →	+1.229	+0.046	<.001	<.001	3	18
OESOPHAGUS	PLEKHA3 →	+0.938	+0.044	.001	.002	2	19
BLOOD_Lymphoma	SMG1 →	+1.336	+0.041	<.001	<.001	3	18
BLOOD_Lymphoma	STRN →	+1.120	+0.042	<.001	<.001	3	17
BLOOD_Lymphoma	TULP4 →	+1.213	+0.040	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006661 vs CCDC93 — OESOPHAGUS

Explore this scatter interactively →