CDP-choline pathway

Across TCGA patient cohorts, RNA activity of the CDP-choline pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JUNB, COL12A1, and FOSL2_S120, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CDP-choline pathway activity versus JUNB in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JUNB →	-0.403	-0.077	<.001	<.001	3	8
OV	COL12A1 →	-0.954	-0.053	<.001	.001	3	7
GBM	FOSL2_S120 →	-0.972	-0.155	<.001	<.001	3	7
HNSC	DDAH1 →	+0.599	+0.085	<.001	.004	3	7
GBM	MMP14 →	-0.428	-0.080	.003	<.001	3	7
PDAC	ACAD8 →	+0.302	+0.044	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006657 vs JUNB — GBM

Explore this scatter interactively →