CDP-choline pathway

Across TCGA cell cohorts, RNA activity of the CDP-choline pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RMC1, C1R, and CEP44, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RMC1 grouped by CDP-choline pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RMC1 →	+0.648	+1.141	<.001	<.001	3	4
OESOPHAGUS	C1R →	-2.821	-1.108	<.001	<.001	3	4
OESOPHAGUS	CEP44 →	-1.092	-1.291	.001	.002	3	4
SKIN	NKX3-1 →	-1.365	-1.146	.003	.002	3	4
SOFT_TISSUE	MTO1 →	+0.806	+1.478	.001	<.001	3	4
BREAST	ZNF384 →	-0.530	-0.695	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RMC1 by CDP-choline pathway activity — OESOPHAGUS

Explore this box plot interactively →