CDP-choline pathway

Across TCGA cell cohorts, RNA activity of the CDP-choline pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBS9, HDAC4, and OARD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CDP-choline pathway activity versus BBS9 in PANCREAS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	BBS9 →	+0.847	+0.284	.001	.003	3	4
BLOOD_Lymphoma	HDAC4 →	+1.336	+0.163	.003	<.001	3	4
PANCREAS	OARD1 →	+0.811	+0.300	.002	<.001	3	4
LUNG_SCLC	TRIM2 →	-1.365	-0.209	.007	.003	3	3
LUNG_SCLC	TKFC →	-0.962	-0.230	<.001	<.001	3	3
OESOPHAGUS	KIAA0895 →	-1.188	-0.207	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006657 vs BBS9 — PANCREAS

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