Phosphatidylcholine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylcholine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JPT1, EIF3F_S258, and RRP9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine biosynthetic process activity versus JPT1 in LUAD (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	JPT1 →	-0.436	-0.059	.001	<.001	3	6
GBM	EIF3F_S258 →	-0.283	-0.040	.004	.007	3	6
LSCC	RRP9 →	-0.322	-0.057	.003	<.001	3	6
BRCA	ESF1_S694 →	-0.747	-0.068	.001	<.001	3	6
LUAD	NOL11 →	-0.257	-0.047	<.001	.001	3	6
LSCC	UTP18 →	-0.293	-0.047	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006656 vs JPT1 — LUAD

Explore this scatter interactively →