Phosphatidylcholine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylcholine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TK1, E2F2, and RPA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine biosynthetic process activity versus TK1 in OV (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TK1 →	-1.042	-0.151	.001	.003	3	4
OV	E2F2 →	-0.931	-0.190	.002	<.001	3	4
CCRCC	RPA4 →	-0.269	-0.118	.004	.003	3	4
LUAD	IQGAP3 →	-0.803	-0.168	.001	.001	3	4
LUAD	CDCA2 →	-0.870	-0.152	<.001	.002	3	4
LUAD	PRR11 →	-0.649	-0.140	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006656 vs TK1 — OV

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