Phosphatidylcholine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAPPA, NUAK2, and OLFML2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAPPA grouped by Phosphatidylcholine biosynthetic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PAPPA →	-1.291	-0.871	.004	.002	3	5
LUNG_NSCLC_LUSC	NUAK2 →	-2.036	-1.353	.002	.002	3	5
OESOPHAGUS	OLFML2A →	-2.457	-0.962	<.001	<.001	3	5
SKIN	TOX2 →	-2.550	-1.095	.003	.005	3	5
URINARY_TRACT	SNX8 →	-0.902	-1.566	.007	.007	3	4
CNS	EPAS1 →	-1.737	-0.886	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAPPA by Phosphatidylcholine biosynthetic process activity — CNS

Explore this box plot interactively →