Phosphatidylcholine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM43, C2orf16, and STOM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine biosynthetic process activity versus RBM43 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RBM43 →	+0.657	+0.933	.009	.009	3	4
UPPER_AERODIGESTIVE_TRACT	C2orf16 →	+0.418	+0.962	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	STOM →	+2.904	+0.747	.001	.005	3	3
LUNG_SCLC	COMMD1 →	+0.436	+0.528	.001	.009	3	3
LUNG_SCLC	ETV5 →	+1.680	+0.703	.002	<.001	3	3
SKIN	B2M →	+1.351	+0.853	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006656 vs RBM43 — UPPER_AERODIGESTIVE_TRACT

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