Diacylglycerol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Diacylglycerol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOCS2, GPRACR, and TRAV6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diacylglycerol biosynthetic process activity versus MOCS2 in OV (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MOCS2 →	-0.620	-0.383	<.001	<.001	3	2
OV	GPRACR →	-0.196	-0.220	.006	.005	3	2
OV	TRAV6 →	-0.404	-0.241	.001	.002	3	2
OV	GPBP1 →	-0.276	-0.254	.007	.001	3	2
OV	DHX29 →	-0.468	-0.199	.001	.002	3	2
LUAD	IMPDH1 →	+0.389	+0.303	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006651 vs MOCS2 — OV

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