Glycerophospholipid metabolic process

Across TCGA patient cohorts, RNA activity of the Glycerophospholipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, RPL5, and SH3BGRL2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid metabolic process activity versus SEPTIN4_S432 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4_S432 →	+0.895	+0.034	.002	<.001	3	9
OV	RPL5 →	-0.184	-0.024	.005	.009	3	8
BRCA	SH3BGRL2 →	+0.581	+0.022	<.001	<.001	3	7
CCRCC	RPL3 →	-0.315	-0.029	<.001	<.001	3	7
CCRCC	RPS2 →	-0.257	-0.019	<.001	.002	3	7
GBM	SEPTIN4 →	+0.553	+0.022	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006650 vs SEPTIN4_S432 — GBM

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