Glycerophospholipid metabolic process

Across TCGA cell cohorts, RNA activity of the Glycerophospholipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMP22, PCYOX1L, and PLCH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMP22 grouped by Glycerophospholipid metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PMP22 →	-3.284	-1.400	.001	<.001	3	4
KIDNEY	PCYOX1L →	-1.061	-1.207	.007	.002	3	4
LUNG_NSCLC_LUSC	PLCH1 →	+0.838	+1.304	.002	.003	3	4
LARGE_INTESTINE	RELCH →	+0.706	+0.609	.009	.009	3	3
BLOOD_Leukemia	CCNH →	-0.613	-0.515	.002	.009	3	3
KIDNEY	TGFBR1 →	-0.962	-1.139	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMP22 by Glycerophospholipid metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →