Glycerophospholipid metabolic process

Across TCGA cell cohorts, RNA activity of the Glycerophospholipid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS4Y1, TTC17, and SLC38A5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS4Y1 grouped by Glycerophospholipid metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RPS4Y1 →	+0.176	+0.170	.006	.006	2	5
BONE	TTC17 →	+0.204	+0.194	.002	<.001	3	3
LUNG_NSCLC_LUAD	SLC38A5 →	+0.168	+0.167	.006	.008	3	3
SKIN	KMT5C →	+0.183	+0.169	.004	.002	3	3
CNS	GLA →	+0.314	+0.196	.008	.007	3	3
CNS	COL6A1 →	+0.325	+0.168	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS4Y1 by Glycerophospholipid metabolic process activity — STOMACH

Explore this box plot interactively →