Glycerophospholipid metabolic process

Across TCGA cell cohorts, RNA activity of the Glycerophospholipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRL, C9orf40, and NEPRO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid metabolic process activity versus PDGFRL in BONE (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PDGFRL →	-1.335	-0.223	.004	.006	3	3
BONE	C9orf40 →	-1.088	-0.315	.001	.003	3	3
BONE	NEPRO →	-0.620	-0.215	<.001	.009	3	3
BONE	MPP5 →	-2.111	-0.319	.001	.004	3	3
OESOPHAGUS	SP110 →	-1.770	-0.152	.004	.006	2	4
KIDNEY	LRBA →	-1.425	-0.212	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006650 vs PDGFRL — BONE

Explore this scatter interactively →