Phosphatidylethanolamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylethanolamine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCYT2, TACC3, and FERMT3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylethanolamine biosynthetic process activity versus PCYT2 in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PCYT2 →	+0.327	+0.067	<.001	<.001	3	7
OV	TACC3 →	-0.496	-0.051	<.001	<.001	3	5
OV	FERMT3 →	-0.468	-0.046	.002	.005	3	5
LSCC	SPR →	+0.472	+0.061	<.001	<.001	3	5
BRCA	THEMIS2 →	-0.474	-0.048	<.001	.001	3	5
LSCC	CD4 →	-0.461	-0.051	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006646 vs PCYT2 — LSCC

Explore this scatter interactively →