Phosphatidylethanolamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylethanolamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLC2, JAML, and LRRK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylethanolamine biosynthetic process activity versus KLC2 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KLC2 →	+0.472	+0.127	<.001	<.001	3	4
UCEC	JAML →	-0.715	-0.217	<.001	<.001	3	4
UCEC	LRRK2 →	-0.793	-0.197	<.001	<.001	3	4
UCEC	GMFG →	-0.847	-0.163	.002	.004	3	4
BRCA	RPS26P28 →	+0.824	+0.139	.009	.005	2	5
OV	THG1L →	-0.622	-0.323	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006646 vs KLC2 — GBM

Explore this scatter interactively →