Phosphatidylethanolamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylethanolamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCBTB2, RIPK2, and CCNY, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCBTB2 grouped by Phosphatidylethanolamine biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RCBTB2 →	-0.920	-0.852	.001	.003	3	3
KIDNEY	RIPK2 →	-1.264	-0.871	<.001	.005	3	3
PANCREAS	CCNY →	-0.700	-1.267	.009	<.001	3	3
PANCREAS	STAM →	-0.648	-1.246	.007	<.001	3	3
PANCREAS	SLFN13 →	-1.952	-0.913	.009	.007	3	3
PANCREAS	CDK1 →	-1.076	-1.094	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCBTB2 by Phosphatidylethanolamine biosynthetic process activity — OVARY

Explore this box plot interactively →