Triglyceride metabolic process

Across TCGA patient cohorts, RNA activity of the Triglyceride metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF4, NCF1C, and PLEKHO2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride metabolic process activity versus NCF4 in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NCF4 →	+1.008	+0.203	<.001	.002	3	7
GBM	NCF1C →	+0.463	+0.145	.002	.005	3	7
GBM	PLEKHO2 →	+0.563	+0.232	.001	.001	3	6
GBM	CD37 →	+0.879	+0.273	<.001	<.001	3	6
OV	MMP19 →	+0.869	+0.157	<.001	<.001	3	6
GBM	MYO1F →	+0.630	+0.203	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006641 vs NCF4 — HNSC

Explore this scatter interactively →