Triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Triglyceride metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EYA2, COL5A2, and TEF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EYA2 grouped by Triglyceride metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EYA2 →	-0.222	-0.680	.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	COL5A2 →	-0.202	-1.438	.002	<.001	3	5
BREAST	TEF →	-0.232	-0.462	<.001	.008	3	5
BLOOD_Leukemia	PARP12 →	-0.256	-0.628	<.001	.008	2	6
BLOOD_Myeloma	SLC7A2 →	-0.165	-1.587	.007	<.001	2	6
LIVER	RNF182 →	-0.268	-0.313	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EYA2 by Triglyceride metabolic process activity — OVARY

Explore this box plot interactively →