Triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Triglyceride metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTPAP, DNAJC22, and SLC37A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride metabolic process activity versus MTPAP in OESOPHAGUS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MTPAP →	-1.150	-0.465	.001	<.001	3	4
LARGE_INTESTINE	DNAJC22 →	+1.304	+0.515	<.001	.002	3	4
KIDNEY	SLC37A2 →	-1.564	-0.280	.004	.004	3	4
LIVER	PLIN1 →	+0.358	+0.305	.005	.004	3	4
KIDNEY	PKIG →	-0.865	-0.308	.009	.003	3	4
BLOOD_Myeloma	POGK →	-0.909	-0.346	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006641 vs MTPAP — OESOPHAGUS

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