Monoacylglycerol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Monoacylglycerol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLA2G4A, PLA2G4A_S437, and PLA2G4A_S434, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoacylglycerol biosynthetic process activity versus PLA2G4A in LUAD (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLA2G4A →	+0.912	+0.090	<.001	<.001	3	7
LUAD	PLA2G4A_S437 →	+1.226	+0.089	<.001	<.001	3	6
LUAD	PLA2G4A_S434 →	+0.892	+0.145	<.001	<.001	3	5
LUAD	TACC2 →	+0.441	+0.084	<.001	<.001	3	4
HNSC	JUP →	+0.442	+0.234	<.001	.001	3	4
LSCC	PLA2G4A_S727 →	+0.979	+0.114	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006640 vs PLA2G4A — LUAD

Explore this scatter interactively →