Monoacylglycerol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Monoacylglycerol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, PAQR8, and ETV4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoacylglycerol biosynthetic process activity versus PLA2G4A in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLA2G4A →	+1.776	+0.563	<.001	<.001	3	8
UCEC	PAQR8 →	+0.723	+0.295	.001	<.001	3	4
UCEC	ETV4 →	+1.267	+0.254	<.001	<.001	3	4
LUAD	CREB3L4 →	-0.347	-0.315	.005	.002	3	4
CCRCC	ACP3 →	+0.486	+0.828	<.001	<.001	3	4
GBM	RASGRP4 →	+0.425	+0.204	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006640 vs PLA2G4A — HNSC

Explore this scatter interactively →