Monoacylglycerol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Monoacylglycerol biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOCT, ABCB6, and H2BC17, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOCT grouped by Monoacylglycerol biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NOCT →	+0.226	+0.163	.003	.001	3	3
LIVER	ABCB6 →	+0.132	+0.251	.004	<.001	3	3
BLOOD_Lymphoma	H2BC17 →	+0.485	+0.223	.006	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	HSD17B2 →	+0.236	+0.219	<.001	.002	3	3
BLOOD_Lymphoma	SLC34A3 →	+0.309	+0.200	.002	<.001	3	3
LUNG_NSCLC_LUAD	HSD17B4 →	-0.146	-0.337	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOCT by Monoacylglycerol biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →