Neutral lipid metabolic process

Across TCGA patient cohorts, RNA activity of the Neutral lipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, RPL38, and SEPTIN4_S117, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral lipid metabolic process activity versus TNS2_S102 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNS2_S102 →	+1.059	+0.030	<.001	<.001	3	7
OV	RPL38 →	-0.503	-0.019	<.001	.001	3	6
CCRCC	SEPTIN4_S117 →	+0.641	+0.021	<.001	<.001	3	6
GBM	SEPTIN4_S432 →	+0.931	+0.032	.001	.002	3	6
LSCC	AGFG2 →	+0.361	+0.030	<.001	<.001	2	7
OV	CYGB →	+0.641	+0.026	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006638 vs TNS2_S102 — OV

Explore this scatter interactively →