Neutral lipid metabolic process

Across TCGA cell cohorts, RNA activity of the Neutral lipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INIP, JAG1, and VASH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral lipid metabolic process activity versus INIP in BONE (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	INIP →	-1.339	-0.320	.009	.001	3	3
LUNG_SCLC	JAG1 →	+2.589	+1.514	.001	<.001	3	3
LARGE_INTESTINE	VASH2 →	-0.704	-0.607	.002	.007	3	3
LARGE_INTESTINE	SCD5 →	-1.405	-0.536	<.001	.001	3	3
LARGE_INTESTINE	ZNF286A →	-0.839	-0.492	.001	.004	3	3
PANCREAS	ITPKB →	-0.687	-0.199	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006638 vs INIP — BONE

Explore this scatter interactively →