Unsaturated fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Unsaturated fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGS2, PLA2G4A, and FCER1G, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Unsaturated fatty acid biosynthetic process activity versus PTGS2 in LSCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTGS2 →	+1.203	+0.238	.005	.001	3	6
COAD	PLA2G4A →	+1.709	+0.233	<.001	<.001	3	5
GBM	FCER1G →	+0.680	+0.160	.005	.007	3	5
GBM	HEXB →	+0.392	+0.237	<.001	<.001	3	5
CCRCC	TNIP3 →	+0.619	+0.114	.002	.007	3	5
COAD	PKD2L1 →	+0.452	+0.130	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006636 vs PTGS2 — LSCC

Explore this scatter interactively →