Unsaturated fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Unsaturated fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD17B7, PDE1C, and MRPL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSD17B7 grouped by Unsaturated fatty acid biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HSD17B7 →	+1.183	+1.201	.003	<.001	3	4
BLOOD_Myeloma	PDE1C →	-0.063	-1.345	.001	.001	3	4
BLOOD_Lymphoma	MRPL4 →	+0.825	+1.536	.001	<.001	3	4
BLOOD_Leukemia	AHCY →	+0.641	+1.398	.003	<.001	3	3
OESOPHAGUS	HOXD11 →	-2.445	-0.977	.001	.003	3	3
OESOPHAGUS	NMB →	-1.649	-0.726	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSD17B7 by Unsaturated fatty acid biosynthetic process activity — STOMACH

Explore this box plot interactively →