Unsaturated fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Unsaturated fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHD4, AFAP1L2, and ARHGAP23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Unsaturated fatty acid biosynthetic process activity versus EHD4 in PANCREAS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EHD4 →	-1.404	-0.324	<.001	.002	3	5
PANCREAS	AFAP1L2 →	-1.603	-0.267	.007	.002	3	5
BONE	ARHGAP23 →	-1.780	-0.430	.008	.005	3	5
KIDNEY	PPARD →	-1.479	-0.229	.004	<.001	3	5
SKIN	PRR22 →	+0.984	+0.268	.003	.005	3	5
LUNG_SCLC	NPC2 →	-1.809	-0.306	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006636 vs EHD4 — PANCREAS

Explore this scatter interactively →