Protein targeting to peroxisome

Across TCGA cell cohorts, RNA activity of the Protein targeting to peroxisome pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKAP2, HIF1A, and MRE11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CKAP2 grouped by Protein targeting to peroxisome-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CKAP2 →	-0.631	-0.970	.005	.001	3	5
OVARY	HIF1A →	-1.459	-1.079	.002	.003	3	4
KIDNEY	MRE11 →	-0.948	-1.307	.002	.006	3	3
KIDNEY	MED17 →	-1.058	-1.548	.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	EXT1 →	-1.550	-0.363	<.001	.001	3	3
BLOOD_Leukemia	ZNF233 →	+0.483	+1.418	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CKAP2 by Protein targeting to peroxisome activity — SOFT_TISSUE

Explore this box plot interactively →