Protein targeting to vacuole

Across TCGA cell cohorts, RNA activity of the Protein targeting to vacuole pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIBADH, RPS6KC1, and AMACR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HIBADH grouped by Protein targeting to vacuole-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HIBADH →	+0.539	+0.214	.005	.001	3	3
LIVER	RPS6KC1 →	-0.686	-0.373	<.001	<.001	3	3
URINARY_TRACT	AMACR →	+1.310	+1.961	.003	<.001	3	3
LARGE_INTESTINE	POMT1 →	-0.623	-0.430	.001	.008	3	3
LARGE_INTESTINE	SH3GL1 →	-0.516	-0.617	.001	.006	3	3
LUNG_NSCLC_LUAD	ADNP2 →	-0.423	-0.327	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HIBADH by Protein targeting to vacuole activity — SKIN

Explore this box plot interactively →