Protein targeting to vacuole

Across TCGA cell cohorts, RNA activity of the Protein targeting to vacuole pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSTM1, SERINC1, and SCARB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein targeting to vacuole activity versus OSTM1 in BONE (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OSTM1 →	+2.177	+0.332	.006	.001	3	7
BLOOD_Lymphoma	SERINC1 →	+0.983	+0.227	.002	.002	3	6
BLOOD_Lymphoma	SCARB2 →	+3.246	+0.304	<.001	<.001	3	6
BONE	CTSA →	+1.700	+0.360	.001	<.001	3	6
BLOOD_Lymphoma	IGF2R →	+1.492	+0.237	<.001	<.001	3	5
BLOOD_Lymphoma	SLC39A1 →	+0.926	+0.254	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006623 vs OSTM1 — BONE

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