Protein targeting to lysosome

Across TCGA cell cohorts, RNA activity of the Protein targeting to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XYLB, RPGRIP1L, and SARAF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XYLB grouped by Protein targeting to lysosome-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	XYLB →	+0.624	+0.766	.003	.007	3	4
LUNG_NSCLC_LUSC	RPGRIP1L →	-0.555	-0.263	.003	.003	3	3
SKIN	SARAF →	+0.493	+0.302	.002	.006	3	3
OVARY	TLE4 →	-2.112	-0.651	<.001	.005	3	3
OVARY	PLEKHA8 →	+0.578	+0.239	.009	.005	3	3
UPPER_AERODIGESTIVE_TRACT	HLA-DRB1 →	-3.211	-0.378	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XYLB by Protein targeting to lysosome activity — BLOOD_Leukemia

Explore this box plot interactively →