Protein targeting to lysosome

Across TCGA cell cohorts, RNA activity of the Protein targeting to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB2, METTL14, and ZMYND11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein targeting to lysosome activity versus SCARB2 in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SCARB2 →	+2.958	+0.201	<.001	<.001	3	7
LUNG_NSCLC_LUAD	METTL14 →	+0.444	+0.152	.001	<.001	3	6
BLOOD_Myeloma	ZMYND11 →	+0.936	+0.285	.004	.002	3	6
LUNG_SCLC	PSMD1 →	+0.660	+0.188	<.001	.003	3	6
BONE	SELENOS →	+1.355	+0.234	.001	.006	3	6
PANCREAS	NPTN →	+1.131	+0.203	.008	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006622 vs SCARB2 — BLOOD_Lymphoma

Explore this scatter interactively →