Protein retention in ER lumen

Across TCGA patient cohorts, RNA activity of the Protein retention in ER lumen pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP7, SEC23A, and SRRM2_S1499, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein retention in ER lumen activity versus FKBP7 in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FKBP7 →	+0.425	+0.055	.003	<.001	3	6
OV	SEC23A →	+0.348	+0.062	<.001	<.001	3	5
BRCA	SRRM2_S1499 →	-0.459	-0.042	<.001	.001	3	5
BRCA	TBC1D2B_S155 →	+0.320	+0.046	.007	.002	3	5
BRCA	CMSS1 →	-0.551	-0.050	<.001	<.001	3	5
GBM	CNN2 →	+0.631	+0.057	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006621 vs FKBP7 — GBM

Explore this scatter interactively →