Protein retention in ER lumen

Across TCGA cell cohorts, RNA activity of the Protein retention in ER lumen pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf115, MARK1, and PLAAT4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf115 grouped by Protein retention in ER lumen-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf115 →	+1.871	+0.715	<.001	.007	3	5
CNS	MARK1 →	+0.972	+0.806	.005	.002	3	5
LUNG_NSCLC_LUAD	PLAAT4 →	-2.331	-1.119	.008	.002	3	5
LIVER	SLC48A1 →	+1.461	+1.119	.002	.004	3	4
LUNG_NSCLC_LUAD	SP110 →	-1.119	-1.002	.001	.001	3	4
PANCREAS	TYSND1 →	+0.548	+1.079	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf115 by Protein retention in ER lumen activity — LARGE_INTESTINE

Explore this box plot interactively →