Protein retention in ER lumen

Across TCGA cell cohorts, RNA activity of the Protein retention in ER lumen pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRTAP5-8, DZIP1, and ERGIC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein retention in ER lumen activity versus KRTAP5-8 in CNS (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRTAP5-8 →	+0.046	+0.272	.004	.001	3	4
UPPER_AERODIGESTIVE_TRACT	DZIP1 →	+1.802	+1.881	.001	<.001	3	4
LIVER	ERGIC2 →	+0.890	+1.482	.009	.006	3	3
LARGE_INTESTINE	EIF3E →	-0.995	-0.361	.009	.003	3	3
URINARY_TRACT	NPNT →	+3.600	+1.599	.003	.001	1	5
STOMACH	FKBPL →	+1.130	+0.555	.003	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006621 vs KRTAP5-8 — CNS

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