Post-translational protein targeting to endoplasmic reticulum membrane

Across TCGA patient cohorts, RNA activity of the Post-translational protein targeting to endoplasmic reticulum membrane pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RALY_S135, SEC63, and WDR20, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-translational protein targeting to endoplasmic reticulum membrane activity versus RALY_S135 in COAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RALY_S135 →	+0.221	+0.029	.001	.002	3	6
BRCA	SEC63 →	+0.493	+0.035	.001	.003	3	5
LSCC	WDR20 →	-0.199	-0.044	<.001	<.001	3	5
LSCC	ARID1B →	+0.201	+0.052	.004	.001	3	5
GBM	TPD52L1 →	+0.632	+0.052	.004	.002	3	5
PDAC	TRPM4 →	-0.489	-0.031	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006620 vs RALY_S135 — COAD

Explore this scatter interactively →