Post-translational protein targeting to endoplasmic reticulum membrane

Across TCGA cell cohorts, RNA activity of the Post-translational protein targeting to endoplasmic reticulum membrane pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBALD1, CNIH1, and RAP1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBALD1 grouped by Post-translational protein targeting to endoplasmic reticulum membrane-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	UBALD1 →	-1.270	-0.910	<.001	.004	3	4
PANCREAS	CNIH1 →	+0.476	+1.016	.008	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	RAP1B →	+1.000	+0.172	<.001	.003	3	3
PANCREAS	MTDH →	+0.838	+1.261	<.001	.001	3	3
PANCREAS	OTUD6B →	+0.831	+1.497	<.001	<.001	3	3
PANCREAS	MEMO1 →	+0.687	+1.460	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBALD1 by Post-translational protein targeting to endoplasmic reticulum membrane activity — OESOPHAGUS

Explore this box plot interactively →