Post-translational protein targeting to endoplasmic reticulum membrane

Across TCGA cell cohorts, RNA activity of the Post-translational protein targeting to endoplasmic reticulum membrane pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5F1A, MGAT1, and TMEM39A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-translational protein targeting to endoplasmic reticulum membrane activity versus ATP5F1A in SOFT_TISSUE (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ATP5F1A →	-0.941	-0.254	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	MGAT1 →	+0.982	+0.168	<.001	.002	3	6
CNS	TMEM39A →	+0.605	+0.149	.009	.003	2	6
CNS	AGRN →	+1.457	+0.140	.001	<.001	3	5
LIVER	SNX18 →	+1.286	+0.238	.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	CLN5 →	+0.755	+0.153	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006620 vs ATP5F1A — SOFT_TISSUE

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