"SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"

Across TCGA patient cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BEST1, KIF27, and TAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" activity versus BEST1 in CCRCC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BEST1 →	-0.616	-0.162	<.001	.003	3	4
HNSC	KIF27 →	-0.407	-0.074	<.001	.001	3	4
BRCA	TAL1 →	-0.336	-0.096	.007	.004	3	4
BRCA	PALM →	-0.849	-0.082	<.001	.001	3	4
PDAC	LMNTD2 →	-0.371	-0.078	.004	.005	3	3
LUAD	SNX9 →	-0.377	-0.090	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006617 vs BEST1 — CCRCC

Explore this scatter interactively →