"SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"

Across TCGA cell cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFS, VAV3, and TMEM265, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EFS grouped by "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EFS →	-0.023	-0.340	.003	.003	3	4
LARGE_INTESTINE	VAV3 →	+4.426	+0.349	<.001	<.001	3	4
LARGE_INTESTINE	TMEM265 →	+2.022	+0.225	.004	.007	3	4
PANCREAS	STS →	+1.473	+0.331	.001	.003	2	4
PANCREAS	AREG →	+3.279	+0.347	<.001	.005	3	3
PANCREAS	HBEGF →	+2.385	+0.347	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EFS by "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" activity — KIDNEY

Explore this box plot interactively →