"SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"

Across TCGA cell cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNB1, SRP72, and NOP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" activity versus KPNB1 in OVARY (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KPNB1 →	+0.749	+0.247	.001	.001	3	6
OVARY	SRP72 →	+0.730	+0.252	.001	.002	3	6
LUNG_NSCLC_LUAD	NOP14 →	+0.585	+0.183	.007	.008	3	5
LIVER	MDC1 →	+1.015	+0.213	.003	.003	3	5
LIVER	UHRF1 →	+0.945	+0.222	.004	.001	3	5
LUNG_SCLC	RPSA →	+0.611	+0.136	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006617 vs KPNB1 — OVARY

Explore this scatter interactively →