"SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"

Across TCGA cell cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRP72, SRP68, and EIF2S3, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition" activity versus SRP72 in STOMACH (Pearson r = 0.86).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SRP72 →	+0.831	+0.274	<.001	<.001	3	18
STOMACH	SRP68 →	+1.081	+0.356	<.001	<.001	3	18
STOMACH	EIF2S3 →	+1.655	+0.323	.002	.002	3	17
OVARY	RPL10A →	+0.716	+0.269	<.001	<.001	3	17
PANCREAS	RPL9 →	+0.757	+0.213	<.001	<.001	3	17
PANCREAS	SRP54 →	+1.018	+0.217	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006617 vs SRP72 — STOMACH

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