SRP-dependent cotranslational protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the SRP-dependent cotranslational protein targeting to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMA4, TINAGL1, and ALDH1L2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SRP-dependent cotranslational protein targeting to membrane activity versus LAMA4 in PDAC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LAMA4 →	+0.202	+0.022	<.001	<.001	3	6
HNSC	TINAGL1 →	+0.424	+0.082	<.001	.002	3	5
CCRCC	ALDH1L2 →	+0.515	+0.033	.003	<.001	3	5
OV	PKP3 →	-0.767	-0.045	<.001	.001	3	5
CCRCC	ACTN1 →	+0.342	+0.039	.008	.002	3	5
CCRCC	MAST4_S1283 →	-0.553	-0.028	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006614 vs LAMA4 — PDAC

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