SRP-dependent cotranslational protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the SRP-dependent cotranslational protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are URGCP, CEP68, and QRICH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SRP-dependent cotranslational protein targeting to membrane activity versus URGCP in LSCC (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	URGCP →	-0.498	-0.137	<.001	<.001	3	5
LSCC	CEP68 →	-0.405	-0.127	<.001	<.001	3	5
LSCC	QRICH2 →	-0.475	-0.073	.002	.005	3	5
LSCC	EXOC6B →	-0.642	-0.105	<.001	<.001	3	5
CCRCC	MIGA2 →	-0.403	-0.230	<.001	<.001	3	5
LSCC	BRD3 →	-0.509	-0.103	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006614 vs URGCP — LSCC

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